Manchester United have been humiliated in West London despite recalling Cristiano Ronaldo to the starting line-up.
David de Gea let Josh DaSilva’s shot slip straight through his hands to get the Bees off the mark early on as Ronaldo appealed in vain for a foul.
Christian Eriksen then lost the ball against his former club to give Mathias Jensen a simple tap in.
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Brentford net their third after Ben Mee outjumped Lisandro Martinez to head in from close range.
Then Bryan Mbeumo slid past De Gea to finish off a brilliant counter-attack which gave the Bees their fourth goal.
This second time the Red Devils will be losing in the season. They lost 2-1 to Brighton on the opening weekend.
The hope for Erik ten Hag’s side to bounce back with strong performances against the Bees in London proved abortive as they were beaten 4-0.